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AIDA64 Extreme Edition 2.30.1911Beta(Murlok) Serial KeySecond-line pemetrexed for platinum-refractory non-squamous non-small cell lung cancer.

The standard of care for patients with non-squamous non-small cell lung cancer who relapse after platinum-based chemotherapy is a second-line chemotherapy regimen including a platinum drug. Pemetrexed is the only approved agent for second-line therapy. We report our experience with a second-line pemetrexed-containing regimen in a tertiary care cancer center in Italy. Between January 2006 and December 2010, we enrolled 51 consecutive patients with platinum-refractory non-squamous non-small cell lung cancer who received pemetrexed as a second-line therapy. All patients received pemetrexed 500 mg/m(2) every 21 days, and patients with symptomatic pleural effusion received a thoracentesis. Of the 51 patients, 42 (82.3%) had received a previous treatment and 24 (47.1%) were chemonaive. The objective response rate was 8.8% (95% CI, 3.1-21.2). The median progression-free and overall survival was 3.5 and 9.4 months, respectively. Treatment was discontinued because of disease progression in 33 (64.7%) patients, whereas the most frequent reason for treatment discontinuation was toxicity (39%). Hematologic toxicity was the most frequent grade 3 or 4 toxicity, with neutropenia occurring in 33 patients (64.7%) and thrombocytopenia in 19 patients (37.3%). Peripheral neuropathy occurred in 14 patients (27.5%). Pemetrexed is a moderately effective regimen for patients with platinum-refractory non-squamous non-small cell lung cancer. Our data suggest that pemetrexed could be considered as the preferred second-line treatment for this population.The Return of The Chronic, Lesser Known Puff Balls

Tuesday, September 22nd, 2010

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